Catalytic Nanozyme for Radiation Protection

  • Ruiying Zhao
    Ruiying Zhao
    Department of Physics, School of Science, Tianjin Chengjian University, Tianjin 300384, China
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  • Haile Liu
    Haile Liu
    Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, Institute of Advanced Materials Physics, School of Science, Tianjin University, Tianjin 300350, China
    More by Haile Liu
  • Yongming Li
    Yongming Li
    Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China
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  • Meili Guo*
    Meili Guo
    Department of Physics, School of Science, Tianjin Chengjian University, Tianjin 300384, China
    *Email: [email protected]
    More by Meili Guo
  • , and 
  • Xiao-Dong Zhang*
    Xiao-Dong Zhang
    Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, Institute of Advanced Materials Physics, School of Science, Tianjin University, Tianjin 300350, China
    Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China
    *Email: [email protected]
Cite this: Bioconjugate Chem. 2021, 32, 3, 411–429
Publication Date (Web):February 11, 2021
https://doi.org/10.1021/acs.bioconjchem.0c00648
Copyright © 2021 American Chemical Society
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Abstract

Radiotherapy has been widely used in clinical cancer treatment. However, the ionizing radiation required to kill the tumor will inevitably cause damage to the surrounding normal tissues. To minimize the radiation damage and side effects, small molecular radioprotective agents have been used as clinical adjuvants for radiation protection of healthy tissues. However, the shortcomings of small molecules such as short circulation time and rapid kidney clearance from the body greatly hinder their biomedical applications. In recent years, nanozymes have attracted much attention because of their potential to treat a variety of diseases. Nanozymes exhibit catalytic properties and antioxidant capabilities to provide a potential solution for the development of high-efficiency radioprotective agents in radiotherapy and nuclear radiation accidents. Therefore, in this review, we systematically summarize the catalytic nanozymes used for radiation protection of healthy tissues and discuss the challenges and future prospects of nanomaterials in the field of radiation protection.

Cited By


This article is cited by 2 publications.

  1. Jiang Liu, Lijun Ma, Guoyang Zhang, Yuzhi Chen, Zhuo Wang. Recent Progress of Surface Modified Nanomaterials for Scavenging Reactive Oxygen Species in Organism. Bioconjugate Chemistry 2021, 32 (11) , 2269-2289. https://doi.org/10.1021/acs.bioconjchem.1c00402
  2. You Liao, Dongmei Wang, Zhanjun Gu. Research Progress of Nanomaterials for Radioprotection. Acta Chimica Sinica 2021, 79 (12) , 1438. https://doi.org/10.6023/A21070319